2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2419):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-180666
    9-Hydroxy-12-oxo-15(Z)-octadecenoic acid
    9-Hydroxy-12-oxo-15(Z)-octadecenoic acid is a metabolite of octadecenoic acid in free fatty acids.
    9-Hydroxy-12-oxo-15(Z)-octadecenoic acid
  • HY-152739
    5-(N-Isopentenyl-N-trifluoroacetyl) aminomethyluridine
    5-(N-Isopentenyl-N-trifluoroacetyl) aminomethyluridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-(N-Isopentenyl-N-trifluoroacetyl) aminomethyluridine
  • HY-154306
    5’-Deoxy-5’-iodo-2’-O-methyluridine
    5’-Deoxy-5’-iodo-2’-O-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5’-Deoxy-5’-iodo-2’-O-methyluridine
  • HY-152970
    7'-O-DMT-morpholino uracil
    7'-O-DMT-morpholino uracil is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.
    7'-O-DMT-morpholino uracil
  • HY-152588
    3’-Deoxy-N1-methyladenosine
    3’-Deoxy-N1-methyladenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-Deoxy-N1-methyladenosine
  • HY-154425
    2-Amino-7-propargyl-7,8-dihydro-8-oxo-9-(beta-D-3-deoxy-ribofuranosyl)purine
    2-Amino-7-propargyl-7,8-dihydro-8-oxo-9-(beta-D-3-deoxy-ribofuranosyl)purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 2-Amino-7-propargyl-7,8-dihydro-8-oxo-9-(beta-D-3-deoxy-ribofuranosyl)purine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    2-Amino-7-propargyl-7,8-dihydro-8-oxo-9-(beta-D-3-deoxy-ribofuranosyl)purine
  • HY-Z12399
    Fosfomycin trometamol impurity 49
    Fosfomycin trometamol impurity 49 (AcDMPt) is a N-acetylated phosphinothricin (Pt) precursor.
    Fosfomycin trometamol impurity 49
  • HY-185603
    m7G(LNA)(5')ppp(5')(2'OMe, m6A)pG trisodium
    m7G(LNA)(5')ppp(5')(2'OMe, m6A)pG trisodium is a cap analog that can be used for the synthesis of mRNA.
    m7G(LNA)(5')ppp(5')(2'OMe, m6A)pG trisodium
  • HY-154432
    N1-Methyl-2’-deoxyinosine
    N1-Methyl-2’-deoxyinosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N1-Methyl-2’-deoxyinosine
  • HY-138588
    7-TFA-ap-7-Deaza-ddA
    7-TFA-ap-7-Deaza-ddA (compound 19c, US20060281100A1), a nucleotide derivative, can be used in the synthesis of thiotriphosphate nucleotide dye terminators which can be used in DNA sequencing reactions.
    7-TFA-ap-7-Deaza-ddA
  • HY-152407
    7-Allyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl) guanine
    7-Allyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl) guanine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    7-Allyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl) guanine
  • HY-138616S2
    dGTP-15N5,d14 dilithium
    dGTP-15N5,d14 (2'-Deoxyguanosine-5'-triphosphate-15N5,d14) dilithium is deuterium and 15N labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
    dGTP-<sup>15</sup>N<sub>5</sub>,d<sub>14</sub> dilithium
  • HY-152579
    6-(1-Piperazinyl)-9-β-D-ribofuranosyl-9H-purine
    6-(1-Piperazinyl)-9-β-D-ribofuranosyl-9H-purine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    6-(1-Piperazinyl)-9-β-D-ribofuranosyl-9H-purine
  • HY-152325
    N1-(N,N-Dimethylaminocarbonyl)-pseudouridine
    N1-(N,N-Dimethylaminocarbonyl)-pseudouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N1-(N,N-Dimethylaminocarbonyl)-pseudouridine
  • HY-152418
    3’-Beta-C-Methyl-N6-(m-methoxybenzyl)adenosine
    3’-Beta-C-Methyl-N6-(m-methoxybenzyl)adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    3’-Beta-C-Methyl-N6-(m-methoxybenzyl)adenosine
  • HY-13640A
    Rabacfosadine succinate
    Rabacfosadine (GS-9219) succinate, a novel proagent of the nucleotide analogue PMEG, is designed as a cytotoxic agent that preferentially targets lymphoid cells.
    Rabacfosadine succinate
  • HY-152355
    N6-Methyl-xylo-adenosine
    N6-Methyl-xylo-adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    N6-Methyl-xylo-adenosine
  • HY-180646
    UDP-α-sulfoquinovose
    UDP-α-sulfoquinovose is a nucleoside metabolite.
    UDP-α-sulfoquinovose
  • HY-152415
    3’-Deoxy-3’-α-C-methyladenosine
    3’-Deoxy-3’-α-C-methyladenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-Deoxy-3’-α-C-methyladenosine
  • HY-154082
    5-Caroxy uracil-1-yl acetic acid benzyl ester
    5-Caroxy uracil-1-yl acetic acid benzyl ester is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Caroxy uracil-1-yl acetic acid benzyl ester